Cannabinerd Newsletter March 25th, 2025
New microbiome study, bioaccumulation of cannabinoids, and clinical trial updates
Science never stands still, and neither do we. As cannabis research expands, so do the questions, debates, and breakthroughs that shape our understanding. This issue dives into everything from the microbiome to cannabinoid bioaccumulation, pain management, and clinical trials testing the limits of minor cannabinoids.
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Stay curious,
The Cannabinerd Team
Featured Studies
1. Gut Reactions: How Cannabis Shapes the Microbiome
Biomedicine & Pharmacotherapy | January 2025
The microbiome is a frontier in medical research, with implications for gut health, weight management, immune function, and even mental well-being. A new systematic review, Cannabis and Cannabinoid-Microbiome Interactions in Varied Clinical Contexts, synthesizes existing studies to explore how cannabis-derived compounds influence microbial diversity across different medical conditions. The findings highlight potential therapeutic benefits but also raise questions about unintended consequences, emphasizing a need to clarify the mechanisms at play. Read the full study here.
2. Cannabinoid Bioaccumulation Questions
Food and Chemical Toxicology | Published March 2025
Could we be underestimating how cannabinoids build up in the body? A new study, Is the Potential for Bioaccumulation of Cannabinoids Underestimated?, uses biomimetic chromatography to explore how cannabinoids interact with biological systems over time. The findings suggest that these compounds may accumulate in ways we don’t yet fully understand, raising questions about long-term exposure, drug interactions, and regulatory thresholds. As cannabis use expands, so does the need to refine our understanding and approach to pharmacokinetics. Read the full study here.
3. What Cannabis Users Really Think About Impaired Driving
AAA Foundation | March 2025
How do cannabis users perceive their ability to drive under the influence, and what messaging might actually deter impaired driving? A new report from the AAA Foundation for Traffic Safety, Examination of Cannabis Users’ Perceptions and Self-Reported Behaviors, dives into user attitudes, risk awareness, and behavioral patterns behind the wheel. The findings reveal gaps in perception versus reality, emphasizing the need for more effective public safety messaging. Understanding these behaviors is key to crafting policies that actually reduce impaired driving incidents. Read the full report here.
Industry White Papers
Who knows the industry better than those who live it? Beneath the headlines and political posturing, white papers tell the deeper story—where cannabis is thriving, where it’s under siege, and where it’s being spun into something it’s not. If you missed these recent reports, they may be worth a read.
Where Will Cannabis Win? (UNLV, March 2025)
This analysis from UNLV examines the shifting landscape of cannabis legalization, predicting which states and markets will emerge as winners in the next wave of reform. It highlights economic trends, policy challenges, and consumer demand shaping the future of the industry.
The Great Hemp Hoax (February 2025)
A deep dive into how hemp’s legal loopholes have been exploited to market intoxicating cannabinoids, this report lays bare the regulatory blind spots fueling the controversy. It challenges industry players and lawmakers to confront the blurred lines between hemp and cannabis.
The Intoxicating Hemp Swindle (Project CBD, March 2025)
Project CBD unpacks the rise of intoxicating hemp-derived cannabinoids, questioning whether this unregulated market is a savvy business innovation or a public health disaster in the making. The report explores legal, scientific, and safety concerns surrounding these products.
Featured Resources
Video:
Cannabinoids and Joint Replacement: Pain and Postoperative Complications – Cerium Journal Club – Experts discuss current research, clinical insights, and potential benefits and risks of cannabinoid-based therapies in orthopedic recovery.
Book to Check out:
Cannabis sativa L. - Botany and Biotechnology. Read a book review here.
Upcoming Online Events:
CBD and Dental Pain: A Breakthrough or a Bite-Sized Solution? (April 1st, 2025, Virtual) – Join this interactive discussion on a recent study examining cannabis and hemp use managing severe tooth pain. Participants will analyze key findings, study limitations, and implications for clinical practice. Learn more.
Cannabis Sciences Virtual Event Series (Lab Roots, April 16, 2025, Virtual) This free virtual event brings together researchers, industry experts, and policymakers to discuss the latest in cannabis science, from lab testing advancements to regulatory updates and clinical research. Learn More.
Upcoming Research Conferences:
o Society of Cannabis Clinicians 3rd Annual Conference (April 2025, Baltimore, MD & Virtual) – Registration is now open for this premier event bringing together medical professionals, researchers, and industry leaders to explore clinical applications of cannabis. Register here.
o ICRS 2025 Conference (June 29–July 4, Toronto, Canada) – The International Cannabinoid Research Society’s annual meeting is open for registration, featuring cutting-edge cannabinoid science. Abstract submissions are closed. Register here
o Cannabis Research Conference 2025 (October 6-8, 2025, Portland, OR) – The Cannabis Research Conference is accepting session proposals until April 7th, for its upcoming conference, bringing together leading scientists, clinicians, and industry. If you’re interested in presenting, session proposals are now open. Submit your proposal here.
Clinical Trial Updates and Announcements
THC/CBD for Pain in Deep Endometriosis (EdomTHC Trial) – This clinical trial is evaluating the effects of a 50% THC / 50% CBD formulation on hyperalgesia (increased pain sensitivity) in patients with deep endometriosis. Researchers aim to assess whether cannabinoids can effectively reduce chronic pain and improve quality of life in those suffering from this debilitating condition. The study will provide insights into the potential of medical cannabis as an alternative or adjunct to conventional pain management strategies. Learn more.
Efficacy and Safety of Hemp-Derived, Full-Spectrum Cannabigerol (CBG) in Adults – This clinical trial is investigating the effects of full-spectrum, hemp-derived CBG on health outcomes in adults, focusing on its potential therapeutic benefits and safety profile. Researchers aim to evaluate CBG’s impact on factors such as pain, inflammation, mood, and overall well-being, contributing to the growing body of evidence on minor cannabinoids. The study will help determine whether CBG could be a viable alternative or complement to existing treatments. Learn more.
CBG Tablets for Sleep Quality in Veterans (ECS21 Trial) – This clinical trial is evaluating the effects of swallowable cannabigerol (CBG) tablets on sleep quality in veterans, a population often affected by sleep disturbances and insomnia. Researchers aim to assess whether CBG can improve sleep duration, efficiency, and overall restfulness, potentially offering a novel cannabinoid-based approach to sleep disorders. The study will provide insights into CBG’s efficacy as a sleep aid and its safety profile. Learn more.
From the Blog O’ Sphere:
Patch On, Peace Out: The Rise of Transdermal Cannabis – This journalistic article from Valley Wellness explores why more consumers are turning to transdermal cannabis products, featuring commentary from industry and healthcare practitioners. Read more.
A Little More Humor to Brighten Your Day (CBD Satire)
This issue of the newsletter is supported by Delaware Analytical, LLC—a licensed analytical laboratory offering accessible and affordable testing for botanical, herbal, and supplement products, as well as soil, water, and hemp. Delaware Analytical provides some of the most cost-effective microbial testing options in the country. The lab is also actively involved in marine conservation, offering testing services for coastal ecosystems. Contact info@delawareanalytical.com to learn more.